Pyridine → (3-Bromo-5-iodo-phenyl)-carbamic acid methyl ester

HRID 1784885

반응식

HRID 1784885 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([I:9])[CH:8]=1)[NH2:5].N1C=CC=CC=1.Cl[C:17]([O:19][CH3:20])=[O:18]>C(Cl)Cl>[CH3:20][O:19][C:17](=[O:18])[NH:5][C:4]1[CH:6]=[C:7]([I:9])[CH:8]=[C:2]([Br:1])[CH:3]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6586Methyl chloroformateHCID 454803883-Bromo-5-iodoaniline

생성물 1

HCID 68843615(3-Bromo-5-iodo-phenyl)-carbamic acid methyl ester수율 99.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 3-bromo-5-iodo-aniline (0.60 g, 2.01 mmol) and pyridine (0.65 mL, 8.06 mmol) in CH2Cl2 (15 mL) at 0° C. was added methyl chloroformate (0.17 mL, 2.22 mmol). The reaction mixture was allowed to warm to room temperature and was stirred for 12 hours. The reaction mixture was washed with twice with 5 mL 1 M HCl and 5 mL brine. The organic layer was dried over Na2SO4 and concentrated to give 0.71 g (99%) of (3-bromo-5-iodo-phenyl)-carbamic acid methyl ester.

후처리

  1. washThe reaction mixture was washed with twice with 5 mL 1 M HCl and 5 mL brine
  2. dry with materialThe organic layer was dried over Na2SO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5d996fc57382415498ebbc3808665e3b
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504401B2

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