Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Acetylbenzonitrile → 3-Isopropenylbenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Acetylbenzonitrile | HCID 80222 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 촉매 | Methyltriphenyliphosphonium bromide | HCID 74505 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Isopropenylbenzonitrile | HCID 12180250 | 86% |
반응 단계
To the methyl triphenylphosphoniumbromide (4.3 grn, 12 mmol) in THF at 0° C., n-BuLi (1.6M, 7.5 ml, 12 mmol) was added and stirred for 30 min. Then 3-acetylbenzonitrile in THF was slowly added and the reaction mixture was stirred at 0° C. for further 3 h. Then reaction mixture was quenched with aqeous ammonium chloride and diluted with ethyl acetate. Organic layer was washed with water, brine and dried. Crude residue after column purification yielded 3-(prop-1-en-2-yl)benzonitrile in 86% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07504420B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-e1d1ebcc11454a64b93acbc82c01bed0 |
| 출처 메모 | uspto-grants-2009_03 |