Water → 3-(4-Chloromethyl-2-methyl-phenyl)-propionic Acid Methyl Ester
반응식
[CH3:1][O:2][C:3](=[O:15])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12]O)=[CH:8][C:7]=1[CH3:14].C(N(CC)CC)C.S(Cl)([Cl:25])=O.O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:15])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][Cl:25])=[CH:8][C:7]=1[CH3:14]참가 물질
6
실험 절차
To a 0° C. solution of 3-(4-Hydroxymethyl-2-methyl-phenyl)-propionic acid methyl ester (1.02 g, 4.90 mmol) in anhydrous CH2Cl2 (15 mL) is added triethylamine (0.75 mL, 5.38 mmol) followed by thionyl chloride (0.40 mL, 5.48 mmol). The mixture is allowed to warm to RT overnight. Water is added, and the mixture is extracted with CH2Cl2. The organics are dried with MgSO4 and concentrated. The crude material is purified by flash chromatography to yield the title compound (1.01 g, 91%).
후처리
- extractionthe mixture is extracted with CH2Cl2
- dry with materialThe organics are dried with MgSO4
- concentrationconcentrated
- customThe crude material is purified by flash chromatography
출처 및 근거
- ORD 기록
- ord-7047c07b8f0142c6b8bef6053ad76cb2
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07504433B2
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