Magnesium → 3-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methyl-propionic acid methyl ester

HRID 1785455노트

반응식

HRID 1785455 반응식
[CH3:1][O:2][C:3](=[O:17])[C:4]([CH3:16])=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([NH2:15])([CH3:14])[CH3:13])[CH:7]=1.[Mg]>CO>[CH3:1][O:2][C:3](=[O:17])[CH:4]([CH3:16])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([NH2:15])([CH3:13])[CH3:14])[CH:7]=1

참가 물질

4

반응물 2

HCID 5462224MagnesiumHCID 690673703-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methylacrylic acid methyl ester

생성물 1

HCID 575931893-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methyl-propionic acid methyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The mixture of 3-[3-(1-amino-1-methyl-ethyl)-phenyl]-2-methylacrylic acid methyl ester (2.0 g, 8.6 mmol), magnesium (0.63 g, 25.8 mmol) in methanol was heated to reflux for 3 h until the starting material was consumed. The mixture was brought to room temperature, filtered and the filtrate was concentrated. The residue obtained was washed with saturated NH4Cl, brine, dried over magnesium sulfate and concentrated.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 3 h until the starting material
  3. customwas consumed
  4. customwas brought to room temperature
  5. filtrationfiltered
  6. concentrationthe filtrate was concentrated
  7. customThe residue obtained
  8. washwas washed with saturated NH4Cl, brine
  9. dry with materialdried over magnesium sulfate
  10. concentrationconcentrated

출처 및 근거

ORD 기록
ord-69ee3bd99eda4cc58d6d1e27af82a7af
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504403B2

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