4-Chloro-2-methylthiopyrimidine → 1-(2-Methylsulfanyl-pyrimidin-4-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

참여 물질

역할	이름	HCID	투입량
반응물	4-Chloro-2-methylthiopyrimidine	HCID 97113	—
반응물	Binap, (A+-)-	HCID 634876	—
반응물	Imidazo(1,2-a)pyridin-5(1H)-one, 2,3-dihydro-7-phenyl-	HCID 3050276	—
반응물	Sodium t-butoxide	HCID 23676156	—
반응물	1-(2-Methylsulfanyl-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one	HCID 57593121	—
용매	Toluene	HCID 1140	—
생성물	1-(2-Methylsulfanyl-pyrimidin-4-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one	HCID 57593160	—

반응 단계

Following the procedure described for the synthesis of 1-(2-methylsulfanyl-pyrimidin -4-yl)-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one, but using 7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one (1 g, 4.7 mmol), sodium tert-butoxide (1.26 g, 13.16 mmol), BINAP (0.43 g, 0.7 mmol), Pd (OAc)2 (0.16 g, 0.7 mmol), toluene (20 mL) and 4-chloro-2-methylthiopyrimidine (0.66 mL, 0.56 mmol). The title compound was isolated as a yellow solid. MS m/e 337 (M+H)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07504403B2
출처 데이터셋	uspto-grants-2009_03
ORD ID	ord-18463e1b15a84f3184de7f73294a6b77
출처 메모	uspto-grants-2009_03