2,4-Dichloropyrimidine → 1-(6-Chloro-pyrazin-2-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

HRID 1785466

반응식

HRID 1785466 반응식
CS[C:3]1[N:8]=[C:7]([N:9]2[C:13]3=[CH:14][C:15]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[CH:16][C:17](=[O:18])[N:12]3[CH2:11][CH2:10]2)[CH:6]=CN=1.[Cl:25]C1N=CC=C(Cl)N=1.C1(C2C=[C:41]3[NH:48]CCN3C(=O)C=2)C=CC=CC=1>>[Cl:25][C:3]1[N:8]=[C:7]([N:9]2[C:13]3=[CH:14][C:15]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[CH:16][C:17](=[O:18])[N:12]3[CH2:11][CH2:10]2)[CH:6]=[N:48][CH:41]=1

참가 물질

4

반응물 3

HCID 775312,4-DichloropyrimidineHCID 3050276Imidazo(1,2-a)pyridin-5(1H)-one, 2,3-dihydro-7-phenyl-HCID 575931601-(2-Methylsulfanyl-pyrimidin-4-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

생성물 1

HCID 575931941-(6-Chloro-pyrazin-2-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

실험 절차

Following the procedure described in the synthesis of 1-(2-methylsulfanyl-pyrimidin -4-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one, but using 2,6-dichloropyrimidine as the coupling component, 7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one (0.5 g, 2.4 mmol) was converted into the title product as a pale yellow solid. MS m/e 325 (M+H)+.

출처 및 근거

ORD 기록
ord-b0cd299ad92a4b7097196a47ab40341a
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504403B2

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