m-Toluohydrazide → 3-Methyl-benzoic acid N'-[4-(3-chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carbonyl]-hydrazide

HRID 1785525

반응식

HRID 1785525 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([N:16]3[C:20]4[CH:21]=[C:22]([O:27][CH3:28])[C:23]([O:25][CH3:26])=[CH:24][C:19]=4[N:18]=[CH:17]3)[S:11][C:12]=2[C:13](O)=[O:14])[CH:5]=[CH:6][CH:7]=1.[C:29]1([CH3:39])[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([NH:37][NH2:38])=[O:36])[CH:30]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([N:16]3[C:20]4[CH:21]=[C:22]([O:27][CH3:28])[C:23]([O:25][CH3:26])=[CH:24][C:19]=4[N:18]=[CH:17]3)[S:11][C:12]=2[C:13]([NH:38][NH:37][C:35](=[O:36])[C:31]2[CH:32]=[CH:33][CH:34]=[C:29]([CH3:39])[CH:30]=2)=[O:14])[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 83082m-ToluohydrazideHCID 236540194-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid

생성물 1

HCID 236545503-Methyl-benzoic acid N'-[4-(3-chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carbonyl]-hydrazide수율 3.8%

실험 절차

In a similar manner as described for Example 53, 4-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid (41 mg, 0.1 mmol) and m-toluic acid hydrazide (15.0 mg, 0.1 mmol, Lancaster) gave 3-Methyl-benzoic acid N′-[4-(3-chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carbonyl]-hydrazide (2.1 mg, 3.8%) as a white solid. MS m/z 548 (M+1).

출처 및 근거

ORD 기록
ord-a9b9f7be58f945379c7e2def803e8dae
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504513B2

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