8-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-one → HCID 11964283, 화합물

HRID 1785552

반응식

HRID 1785552 반응식
[C:1]1([C:7]2[O:11][C:10]([NH:12][C:13]3[CH:14]=[CH:15][CH:16]=[C:17]4[C:22]=3[CH2:21][C:20](=[O:23])[CH2:19][CH2:18]4)=[N:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C1C=CC(C2OC(NC3C=CC=C4C=3CC(=O)CC4)=NC=2)=CC=1>>[C:1]1([C:7]2[O:11][C:10]([NH:12][C:13]3[CH:14]=[CH:15][CH:16]=[C:17]4[C:22]=3[CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]4)=[N:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 2

HCID 119558408-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-oneHCID 119642378-[(5-phenyl-1,3-oxazol-2-yl)amino]-3,4-dihydronaphthalen-2(1H)-one

생성물 1

HCID 11964283HCID 11964283, 화합물

실험 절차

The title compound was prepared using the procedure as described in Example 2, substituting the product of Example 11C for the product of Example 1I. 1H NMR (DMSO-d6) 9.11 (s, 1H), 7.59 (m, 3H), 7.41 (t, 2H, J=7.7 Hz), 7.37 (s, 1H), 7.25 (t, 1H, J=7.5 Hz), 7.09 (t, 1H, J=7.5 Hz), 6.84 (d, 1H, J=7.1 Hz), 4.80 (d, 1H, J=4.1 Hz), 3.93 (m, 1H), 2.73-2.99 (m, 4H), 1.86 (m, 1H), 1.62 (m, 1H); MS (ESI+) m/z 307 (M+H).

출처 및 근거

ORD 기록
ord-9b104f7949564704b58f3de63e4cd4fe
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504520B2

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