Isocyanate → 3-[2-(trifluoromethyl)-4-fluoro-4'-chlorobenzhydryloxy]-N-(benzyl)azetidine-1-carboxamide

HRID 1785681노트

반응식

HRID 1785681 반응식
Cl.[F:2][C:3]([F:25])([F:24])[C:4]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][NH:17][CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1.[N-:26]=[C:27]=[O:28]>>[F:25][C:3]([F:2])([F:24])[C:4]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][N:17]([C:27]([NH:26][CH2:3][C:4]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:5]=2)=[O:28])[CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1

참가 물질

3

반응물 2

HCID 105034IsocyanateHCID 866111613-[2-(Trifluoromethyl)-4-fluoro-4'-chlorobenzhydryloxy]azetidine hydrochloride

생성물 1

HCID 112948303-[2-(trifluoromethyl)-4-fluoro-4'-chlorobenzhydryloxy]-N-(benzyl)azetidine-1-carboxamide

실험 절차

This material was prepared 3-[2-(trifluoromethyl)-4-fluoro-4′-chlorobenzydryloxy]azetidine hydrochloride (125) and the corresponding isocyanate using the procedure described for compound (10).

출처 및 근거

ORD 기록
ord-79eabd33bc1948d7a4fec8762ba70161
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504522B2

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