Isocyanate → 3-[2-(trifluoromethyl)-4'-(trifluoromethoxy)benzhydryloxy]-N-(benzyl)azetidine-1-carboxamide

반응식

Cl.[F:2][C:3]([F:28])([F:27])[C:4]1[CH:26]=[CH:25][CH:24]=[CH:23][C:5]=1[CH:6]([O:18][CH:19]1[CH2:22][NH:21][CH2:20]1)[C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=1.[N-:29]=[C:30]=[O:31]>>[F:28][C:3]([F:27])([F:2])[C:4]1[CH:26]=[CH:25][CH:24]=[CH:23][C:5]=1[CH:6]([O:18][CH:19]1[CH2:22][N:21]([C:30]([NH:29][CH2:3][C:4]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:5]=2)=[O:31])[CH2:20]1)[C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=1

참가 물질

반응물 2

HCID 105034Isocyanate

HCID 86611163HCID 86611163, 화합물

생성물 1

HCID 112146223-[2-(trifluoromethyl)-4'-(trifluoromethoxy)benzhydryloxy]-N-(benzyl)azetidine-1-carboxamide

실험 절차

This material was prepared from 3-[2-(trifluoromethyl)-4′-(trifluoro-methoxy)benzyloxy]azetidine hydrochloride (141) and the corresponding isocyanate using the procedure described for compound (10).

출처 및 근거

ORD 기록: ord-0a57622721f94871b78cbeb723f2fc01
출처 데이터셋: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07504522B2

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