4-Methylbenzaldehyde → p-Tolyl(2-(trifluoromethyl)phenyl)methanol

HRID 1785695노트

반응식

HRID 1785695 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Mg]Br.[C:13]1([CH3:21])[CH:18]=[CH:17][C:16]([CH:19]=[O:20])=[CH:15][CH:14]=1.FC(F)(F)C1C=C(Cl)C=CC=1C(O)C1C=CC=CC=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:19]([OH:20])[C:16]1[CH:17]=[CH:18][C:13]([CH3:21])=[CH:14][CH:15]=1

참가 물질

4

반응물 3

HCID 77254-MethylbenzaldehydeHCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 178506141HCID 178506141, 화합물

생성물 1

HCID 13309099p-Tolyl(2-(trifluoromethyl)phenyl)methanol

실험 절차

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (16 mmol) and p-tolualdehyde (1.82 mL, 15 mmol) using the procedure described for compound (96) (4.28 g, 100%).

출처 및 근거

ORD 기록
ord-d05f8651193c4d94b238cc07cd1ed39b
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504522B2

반응 노트

불러오는 중…