1-(Diphenylmethyl)azetidin-3-ol → 1-Benzhydryl-3-[2-(trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine

HRID 1785707노트

반응식

HRID 1785707 반응식
[CH:1]([N:14]1[CH2:17][CH:16]([OH:18])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:19][C:20]([F:37])([F:36])[C:21]1[CH:35]=[CH:34][CH:33]=[CH:32][C:22]=1[CH:23](O)[C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1.C(N1CC(OC(C2C=CC(Cl)=CC=2)C2C=CC(Cl)=CC=2Cl)C1)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH:1]([N:14]1[CH2:17][CH:16]([O:18][CH:23]([C:24]2[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=2)[C:22]2[CH:32]=[CH:33][CH:34]=[CH:35][C:21]=2[C:20]([F:37])([F:36])[F:19])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 3304481-(Diphenylmethyl)azetidin-3-olHCID 49963912(4-Fluorophenyl)[2-(trifluoromethyl)phenyl]methanolHCID 689038181-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidine

생성물 1

HCID 689032081-Benzhydryl-3-[2-(trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine

실험 절차

This material was prepared from 1-benzhydryl-3-azetidinol (1) (7.5 mmol) and 2-(trifluoromethyl)-4′-fluorobenzhydrol (160) (15 mmol) using the procedure described for compound (3). After basic aqueous workup, the crude product was used in the next step without further purification.

후처리

  1. customAfter basic aqueous workup, the crude product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-62fbb1e06dcc4cf48b8456677bf4b467
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504522B2

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