4-(Methylsulfonyl)benzaldehyde → 2-(Trifluoromethyl)-4'-(methylsulfonyl)benzhydrol

HRID 1785715노트

반응식

HRID 1785715 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Mg]Br.[CH3:13][S:14]([C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=1)(=[O:16])=[O:15].FC(F)(F)C1C=C(Cl)C=CC=1C(O)C1C=CC=CC=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:21]([OH:22])[C:20]1[CH:19]=[CH:18][C:17]([S:14]([CH3:13])(=[O:16])=[O:15])=[CH:24][CH:23]=1

참가 물질

4

반응물 3

HCID 2203764-(Methylsulfonyl)benzaldehydeHCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 178506141HCID 178506141, 화합물

생성물 1

HCID 689024622-(Trifluoromethyl)-4'-(methylsulfonyl)benzhydrol수율 108.6%

실험 절차

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (14.5 mmol) and 4-(methylsulfonyl)benzaldehyde (2.68 g, 13.8 mmol) using the procedure described for compound (96). The product was obtained as an amber gum (4.95 g, 100%).

출처 및 근거

ORD 기록
ord-dde7f526db1f4046aa203d05de1beca4
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504522B2

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