Trimethylsilyldiazomethane → 2-Tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester

HRID 1786046노트

반응식

HRID 1786046 반응식
[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:13][CH2:14][OH:15])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:16][Si](C=[N+]=[N-])(C)C>CO>[CH3:16][O:11][C:10](=[O:12])[CH:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:13][CH2:14][OH:15]

참가 물질

4

반응물 2

HCID 167693TrimethylsilyldiazomethaneHCID 41186272-(((Tert-butoxy)carbonyl)amino)-4-hydroxybutanoic acid

생성물 1

HCID 68578092-Tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-tert-Butoxycarbonylamino-4-hydroxy-butyric acid (0.79 g, 3.6 mmol) was dissolved in 15 ml methanol at room temperature and (trimethylsilyl)diazomethane (2M solution in hexane) was added till solution become yellow. The mixture was concentrated down to afford crude 2-tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester.

후처리

  1. concentrationThe mixture was concentrated down

출처 및 근거

ORD 기록
ord-5ce92dc187844cc28977b7bd81bea19d
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504508B2

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