9-Bromo-2-methoxymethyl-6H-1,3,3a,6-tetraaza-benzo[e]azulen-5-one → 9-Bromo-2-methoxymethyl-5-[1,2,4]triazol-1-yl-4H-1,3,3a,6-tetraaza-benzoazulene
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:14][C:13](=O)[CH2:12][N:11]3[C:7](=[N:8][C:9]([CH2:16][O:17][CH3:18])=[N:10]3)[C:6]=2[CH:19]=1.ClC1C=CC2NC(=O)C[N:30]3[C:26](=[N:27][C:28](COC)=[N:29]3)C=2C=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:14]=[C:13]([N:29]3[CH:28]=[N:27][CH:26]=[N:30]3)[CH2:12][N:11]3[C:7]([C:6]=2[CH:19]=1)=[N:8][C:9]([CH2:16][O:17][CH3:18])=[N:10]3참가 물질
3
실험 절차
As described for example 4e) 9-bromo-2-methoxymethyl-6H-1,3,3a,6-tetraaza-benzo[e]azulen-5-one (12.5 g, 38.7 mmol), instead of 9-chloro-2-methoxymethyl-6H-1,3,3a,6-tetraaza-benzo[e]azulen-5-one, was converted to the title compound (11.4 g, 79%) which was obtained as a light yellow solid. MS: m/e=373.0/375.1 [M+H]+.
출처 및 근거
- ORD 기록