Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl piperazine-1-carboxylate → [6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4-cyclopropanesulfonyl-piperazin-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 반응물 | Cyclopropanesulfonyl chloride | HCID 2760919 | — |
| 반응물 | 1-(Cyclopropylsulfonyl)piperazine | HCID 45496790 | — |
| 반응물 | 6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid hydrochloride | HCID 67017930 | — |
| 생성물 | [6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4-cyclopropanesulfonyl-piperazin-1-yl)-methanone | HCID 68566781 | 62% |
반응 단계
The title compound was synthesized in analogy to example 1, from 6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate a) and cyclopropylsulfonyl-piperazine (prepared in analogy to International Patent Application Publ. No. WO 2003/064413 by using cyclopropylsulfonyl chloride and tert-butyl 1-piperazinecarboxylate) to afford the title compound as a light-yellow solid (62%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07507736B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-2200d6b7e9f94cecbba6c389b32d518b |
| 출처 메모 | uspto-grants-2009_03 |