HCID 131727367, 화합물 → HCID 57597585, 화합물

HRID 1786537노트

반응식

HRID 1786537 반응식
C([N:9]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:36])[C:15](=[O:35])[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)[C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH2:10]1)(=O)C1C=CC=CC=1>CO.[Pd]>[CH3:36][N:14]([C@@H:11]1[CH2:12][CH2:13][NH:9][CH2:10]1)[C:15](=[O:35])[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]([C:21]1[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=1)[C:28]1[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=1

참가 물질

4

반응물 1

HCID 131727367HCID 131727367, 화합물

생성물 1

HCID 57597585HCID 57597585, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 6,6-Bis-(4-fluoro-phenyl)-hexanoic acid(1-benzoyl-pyrrolidin-3-yl)-methyl amide(1.0 g, 2.1 mmol in CH3OH (50 ml) was added Pd/C 20% (250 mg). The resulting slurry was hydrogenated at 50 psi for 24 hours. The catalyst was filtered through Celite and filtrate evaporated under reduced pressure to give 0.78 g of desired product.

후처리

  1. filtrationThe catalyst was filtered through Celite and filtrate
  2. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-dc32dab8144d4f6a9059963a3961787d
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07507760B2

반응 노트

불러오는 중…