(Isocyanatomethylene)dibenzene → 1-Benzhydryl-3-(1-benzhydryl-2-oxo-pyrrolidin-3-yl)-urea

HRID 1786559

반응식

HRID 1786559 반응식
[NH2:1][CH:2]1[CH2:6][CH2:5][N:4]([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:3]1=[O:20].[C:21]1([CH:27]([N:34]=[C:35]=[O:36])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(Cl)Cl>[CH:27]([NH:34][C:35]([NH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:3]1=[O:20])=[O:36])([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

4

반응물 2

HCID 4250935(Isocyanatomethylene)dibenzeneHCID 575975623-Amino-1-benzhydryl-pyrrolidin-2-one

생성물 1

HCID 575975821-Benzhydryl-3-(1-benzhydryl-2-oxo-pyrrolidin-3-yl)-urea수율 65%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-amino-1-benzhydryl-pyrrolidin-2-one (42) (0.2 g, 0.75 mmol) in dry CH2Cl2 (15 ml) was added diphenylmethyl isocyanate (0.17 mg, 0.82 mmol) dropwise under nitrogen. The resulting mixture was stirred at room temperature for two days followed by refluxing for 5 hours. Removal of solvent under reduced pressure followed by column chromatography using hexane: ethyl acetate (2:1) gave the desired product in 65% yield.

후처리

  1. temperatureby refluxing for 5 hours
  2. customRemoval of solvent under reduced pressure

출처 및 근거

ORD 기록
ord-90252da0f3144d0e85fb42da01f4d4d5
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07507760B2

연결된 노트

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