Formamidine acetate → 6-(furan-2-yl)-5H-pyrrolo[3,2-d]pyrimidin-4-ol
반응식
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[O:8][CH:9]=[CH:10][CH:11]=2)[NH:4][C:3]=1[C:12]([O:14]CC)=O.C(O)(=O)C.[CH:21](N)=[NH:22]>C(O)C>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[NH:4][C:3]2[C:12](=[O:14])[NH:22][CH:21]=[N:1][C:2]=2[CH:6]=1참가 물질
4
실험 절차
To a solution of ethyl 3-amino-5-(2-furyl)-1H-pyrrole-2-carboxylate (2.58 g) in ethanol (35 mL) was added formamidine acetate (1.83 g), and the mixture was heated under reflux for 18 hrs. After cooling to room temperature, the precipitated solid was collected by filtration, washed with ethanol, and dried under reduced pressure at 60° C. to give the title compound (2.26 g).
후처리
- temperaturethe mixture was heated
- temperatureunder reflux for 18 hrs
- filtrationthe precipitated solid was collected by filtration
- washwashed with ethanol
- customdried under reduced pressure at 60° C.
출처 및 근거
- ORD 기록
- ord-95a54f43fb5e4d08b1d87ebe133e79b5
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07507740B2
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