2,3,5-Trimethylphenol → 4-Bromo-1-(4-isopropylphenyl)-2-(2,3,5-trimethylphenoxy)ethanone

HRID 1787143노트

반응식

HRID 1787143 반응식
CC1C(C)=CC(C)=CC=1O.[Br:11][C:12]1[C:17]([CH3:18])=[CH:16][C:15]([OH:19])=[C:14]([CH3:20])[C:13]=1[CH3:21].Br[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][C:29]([CH:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=1)=[O:25]>C(OCC)(=O)C.CCCCCC>[Br:11][C:12]1[C:17]([CH3:18])=[CH:16][C:15]([O:19][CH2:23][C:24]([C:26]2[CH:31]=[CH:30][C:29]([CH:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=2)=[O:25])=[C:14]([CH3:20])[C:13]=1[CH3:21]

참가 물질

5

반응물 3

HCID 127692,3,5-TrimethylphenolHCID 36293344-Bromo-2,3,5-trimethylphenolHCID 140427562-Bromo-1-(4-(propan-2-yl)phenyl)ethan-1-one

생성물 1

HCID 231143254-Bromo-1-(4-isopropylphenyl)-2-(2,3,5-trimethylphenoxy)ethanone수율 51%

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

Using 2,3,5-trimethylphenol, 4-bromo-2,3,5-trimethylphenol was synthesized in the same manner as in Reference Example 23. Using this compound and 2-bromo-1-(4-isopropylphenyl)ethanone obtained in Reference Example 164, the title compound was synthesized in the same manner as in Reference Example 159. Yield 51%. Melting point: 71-72° C. (ethyl acetate-hexane).

후처리

  1. customwas synthesized in the same manner as in Reference Example 23
  2. customobtained in Reference Example 164

출처 및 근거

ORD 기록
ord-cf23ff1a360c478e808d10ef0f6751b0
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07507841B2

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