{2-[3-(3-Bromo-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester → 4-(3-Bromo-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 1787418노트

반응식

HRID 1787418 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:30])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([Br:29])[CH:24]=1)=O)(C)(C)C>C(O)(C(F)(F)F)=O>[Br:29][C:25]1[CH:24]=[C:23]([C:21]2[CH2:20][C:19](=[O:30])[NH:18][C:9]3[CH:10]=[C:11]([C:14]([F:17])([F:16])[F:15])[CH:12]=[CH:13][C:8]=3[N:7]=2)[CH:28]=[CH:27][CH:26]=1

참가 물질

3

반응물 1

HCID 86623847{2-[3-(3-Bromo-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester

생성물 1

HCID 673618184-(3-Bromo-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

) The title compound was prepared from the above described {2-[3-(3-bromo-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (1.152 g, 2.30 mmol) and TFA (10 mL) according to general procedure I step 2. Obtained as a light yellow solid (0.730 g, 82%). MS (ISP) 383.0 [(M+H)+] and 385.0 [(M+2+H)+].

출처 및 근거

ORD 기록
ord-daae4e2bc2b94444b3f4b9cd9502bddc
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511033B2

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