6-ethyl-3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one → HCID 68487141, 화합물
반응식
[CH2:1]([N:3]1[C:8](=[O:9])[C:7]2=[N:10][O:11][C:12]([CH3:13])=[C:6]2[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4]1)[CH3:2]>[Pd].C(O)C>[C:12]([C:6]1[C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[N:4][N:3]([CH2:1][CH3:2])[C:8](=[O:9])[C:7]=1[NH2:10])(=[O:11])[CH3:13]참가 물질
4
실험 절차
A mixture of 6-ethyl-3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one (Dal Piaz, V et al., J. Med. Chem. 1997, 40, 1417) (2.0 g, 7.83 mmol) and 10% palladium on charcoal (400 mg) in ethanol (400 mL) was shaken under hydrogen at room temperature and 2 bar for 3 h. The catalyst was filtered off and the solvent was removed under reduced pressure to yield the title compound (98% yield).
후처리
- filtrationThe catalyst was filtered off
- customthe solvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-87d860f938a449fe8a358516e5a91569
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07511038B2
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