3-Pyridinepropanoic acid, beta-oxo-, methyl ester → HCID 178486501, 화합물

HRID 1787537

반응식

HRID 1787537 반응식
[NH:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:7]=1[NH2:8].CO[C:19](=O)[CH2:20][C:21](=[O:28])[C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1>>[CH3:16][O:15][C:10]1[C:11]([O:13][CH3:14])=[CH:12][C:6]2[C:2]3[N:3]([CH2:4][CH2:5][N:1]=3)[C:19](/[CH:20]=[C:21](/[C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)\[OH:28])=[N:8][C:7]=2[CH:9]=1

참가 물질

3

반응물 2

HCID 1086453-Pyridinepropanoic acid, beta-oxo-, methyl esterHCID 57599792HCID 57599792, 화합물

생성물 1

HCID 178486501HCID 178486501, 화합물수율 28.1%

실험 절차

A mixture of 2-(4,5-dihydro-1H-imidazol-2-yl)-4,5-dimethoxyaniline (0.15 g, 0.68 mmol) and methyl-3-oxo-3(3-pyridinyl)propanoate (0.20 g, 1.12 mmol) was stirred at 155. for 1 hour. The reaction mixture was purified by column chromatography on silica-gel (dichloromethane/methanol, 25/1) to give (Z)-2-(8,9-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-1-(3-pyridinyl)ethenol (66.9 mg, 28%) as a yellow solid.

후처리

  1. customThe reaction mixture was purified by column chromatography on silica-gel (dichloromethane/methanol, 25/1)

출처 및 근거

ORD 기록
ord-0944fbcff90e4f7199175239c9b25760
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511041B2

연결된 노트

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