1-Methyl-3-aminopyrazole → HCID 16118956, 화합물

반응식

Br[C:2]1[CH:11]=[N:10][C:9](Cl)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[N:13]1[CH:18]=[C:17](B(O)O)[CH:16]=[CH:15][CH:14]=1.[CH3:22][N:23]1[CH:27]=[CH:26][C:25]([NH2:28])=[N:24]1>>[CH3:22][N:23]1[CH:27]=[CH:26][C:25]([NH:28][C:9]2[N:10]=[CH:11][C:2]([C:15]3[CH:14]=[N:13][CH:18]=[CH:17][CH:16]=3)=[C:3]3[C:8]=2[N:7]=[CH:6][CH:5]=[CH:4]3)=[N:24]1

참가 물질

반응물 3

HCID 1372541-Methyl-3-aminopyrazole

HCID 27343783-Pyridinylboronic acid

HCID 422813655-Bromo-8-chloro-1,7-naphthyridine

생성물 1

HCID 16118956HCID 16118956, 화합물

실험 절차

The title compound, MS: m/e=303.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 5-bromo-8-chloro-[1,7]naphthyridine (Example H), 5-pyridineboronic acid and 1-methyl-1H-pyrazol-3-ylamine.

출처 및 근거

ORD 기록: ord-0740054aff2446f588012d2b2a5ba8cd
출처 데이터셋: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07511055B2

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