2-Amino-4-methylthiazole → (2-Methyl-5-pyridin-3-yl-[1,7]naphthyridin-8-yl)-(4-methyl-thiazol-2-yl)-amine

반응식

Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[N:14]1[CH:19]=[CH:18][CH:17]=[C:16](B(O)O)[CH:15]=1.[NH2:23][C:24]1[S:25][CH:26]=[C:27]([CH3:29])[N:28]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:23][C:24]3[S:25][CH:26]=[C:27]([CH3:29])[N:28]=3)[N:3]=[CH:4][C:5]=2[C:16]2[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=2)[N:10]=1

참가 물질

반응물 3

HCID 741432-Amino-4-methylthiazole

HCID 27343783-Pyridinylboronic acid

HCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

생성물 1

HCID 16118959(2-Methyl-5-pyridin-3-yl-[1,7]naphthyridin-8-yl)-(4-methyl-thiazol-2-yl)-amine

실험 절차

The title compound, MS: m/e=334.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-pyridineboronic acid and 2-amino-4-methylthiazole.

출처 및 근거

ORD 기록: ord-cac6be2d6fc7493b92cebf7e16bb87d5
출처 데이터셋: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07511055B2

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