Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 4-(Piperidine-1-sulfonyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N-(4-(1-Piperidinylsulfonyl)phenyl)acetamide | HCID 79780 | — |
| 반응물 | Dichloromethane ethylacetate | HCID 21226138 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 4-(Piperidine-1-sulfonyl)aniline | HCID 236648 | 70.62% |
반응 단계
N-[4-(Acetylamino)phenylsulfonyl]piperidine (Example 5) was heated at 100° C. in 20% hydrochloric acid (5 mL) for one hour (TLC ethyl acetate/dichloromethane 8:2). The solution is neutralized at 0° C. with NaOH. The precipitate that forms is filtered and recrystallized from methanol/diethyl ether to afford the desired N-[4-(amino)phenylsulfonyl]piperidine. 70.62% yield; white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07511133B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-72f5b3bac1774de1a6a19a42599f80db |
| 출처 메모 | uspto-grants-2009_03 |