4-Chloro-2-(4-phenylpiperazin-1-yl)-6,7-dihydrothieno[3,2-d]pyrimidine → (2-Piperazin-1-yl-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)propylamine

HRID 1788013노트

반응식

HRID 1788013 반응식
Cl[C:2]1[C:3]2[S:22][CH2:21][CH2:20][C:4]=2[N:5]=[C:6]([N:8]2[CH2:13][CH2:12][N:11](C3C=CC=CC=3)[CH2:10][CH2:9]2)[N:7]=1.[CH:23]1([NH:29]C2C3SCCC=3N=C(N3CCN(C4C=CC(C(OCC)=O)=CC=4)CC3)N=2)CCC[CH2:25][CH2:24]1>O1CCOCC1>[N:8]1([C:6]2[N:7]=[C:2]([CH2:25][CH2:24][CH2:23][NH2:29])[C:3]3[S:22][CH2:21][CH2:20][C:4]=3[N:5]=2)[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

참가 물질

4

반응물 2

HCID 866162644-Chloro-2-(4-phenylpiperazin-1-yl)-6,7-dihydrothieno[3,2-d]pyrimidineHCID 86616266Ethyl 4-[4-(4-cyclohexylamino-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)piperazin-1-yl]benzoate

생성물 1

HCID 68438559(2-Piperazin-1-yl-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)propylamine수율 80%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

1.0 g (4.4 mmol) of (2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)propylamine (V) and 1.9 g (21.8 mmol) of piperazine (VI) are placed in 10 mL of dioxane, then reacted for 0.7 hours at 150° C. in the microwave. Then the reaction mixture is extracted with water and ethyl acetate, and the organic phase is dried and evaporated to dryness. The residue is triturated with petroleum ether and suction filtered. 0.97 g of product VII (80%) is obtained as a powder.

후처리

  1. customreacted for 0.7 hours at 150° C. in the microwave
  2. extractionThen the reaction mixture is extracted with water and ethyl acetate
  3. customthe organic phase is dried
  4. customevaporated to dryness
  5. customThe residue is triturated with petroleum ether and suction
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-23e22e80c1564ca08293ef3f42cc469e
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511045B2

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