6-bromo-N-methylnaphthalen-2-amine → HCID 68903420, 화합물

HRID 1788337

반응식

HRID 1788337 반응식
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([NH:12][CH3:13])[CH:6]=[CH:5]2.[Cu][C:15]#[N:16]>N1C=CC=CC=1>[CH3:13][NH:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[CH:3]=[C:2]([C:15]#[N:16])[CH:11]=[CH:10]2

참가 물질

4

반응물 2

HCID 3000586-bromo-N-methylnaphthalen-2-amineHCID 178418546HCID 178418546, 화합물

생성물 1

HCID 68903420HCID 68903420, 화합물수율 71%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
220 °C

실험 절차

A solution of 6-bromo-N-methyl-2-naphthylamine (2.0 g, 8.5 mmol) in pyridine (50 ml) was added to copper (I) cyanide (1.1 g, 12.3 mmol). The mixture was stirred at 220° C. for 4 hours. The reaction mixture was allowed to cool to room temperature, extracted with dichloromethane, washed with an aqueous solution of hethylene diamine (10 vol %), and purified by column chromatography using hexane/ethyl acetate (4:1) as an eluting solvent to give the title compound (1.1 g, yield: 71%).

후처리

  1. temperatureto cool to room temperature
  2. extractionextracted with dichloromethane
  3. washwashed with an aqueous solution of hethylene diamine (10 vol %)
  4. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-a91725a931084092b21bc00e3cae7e72
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511167B2

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