Ethyl 4-(cyclohexylamino)-3-nitrobenzoate → Ferrostatin-1

HRID 1788405

반응식

HRID 1788405 반응식
[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[C:7]([N+:18]([O-])=O)[CH:6]=1)[CH3:2]>C(OCC)(=O)C.CO.[Pd]>[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)=[C:7]([NH2:18])[CH:6]=1)[CH3:2]

참가 물질

5

반응물 1

HCID 5298559Ethyl 4-(cyclohexylamino)-3-nitrobenzoate

생성물 1

HCID 4068248Ferrostatin-1

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 5.84 g (20 mmol) of Compound 10 in 50 mL ethyl acetate and 30 mL methanol, 100 mg of 10% Pd/C was added, and the mixture was hydrogenated at 30 psi for 6 h. The catalyst was removed by filtration through a pad of Celite, the solvent was evaporated to dryness resulting in a dark purple solid which was recrystallized from ether-hexane. The mother liquid was evaporated, and the resulting solid was suspended in hexane and filtered to give additional yield of Compound 11

후처리

  1. customThe catalyst was removed by filtration through a pad of Celite
  2. customthe solvent was evaporated to dryness
  3. customresulting in a dark purple solid which
  4. customwas recrystallized from ether-hexane
  5. customThe mother liquid was evaporated
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-29174407198c49d7a92d8befd421f1d3
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511145B2

연결된 노트

불러오는 중…