Benzil → 1-Cyclohexyl-2-(2,3-diphenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid

HRID 1788450노트

반응식

HRID 1788450 반응식
[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:24]=[CH:23][C:22]([NH2:25])=[C:21]([NH2:26])[CH:20]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:27]1([C:33]([C:35]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=O)=O)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:20]=[C:21]3[C:22](=[CH:23][CH:24]=2)[N:25]=[C:35]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:33]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[N:26]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 8651BenzilHCID 689222991-Cyclohexyl-2-(3,4-diaminophenyl)-1H-benzimidazole-5-carboxylic Acid

생성물 1

HCID 52760271-Cyclohexyl-2-(2,3-diphenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid

실험 절차

A solution of 100 mg (0.29 mmol) of Compound 406b and 74 mg (0.35 mmol) of benzil was stirred at room temperature overnight. The solvent was evaporated and the residue was purified on preparative HPLC yielding 10 mg.

후처리

  1. customThe solvent was evaporated
  2. customthe residue was purified on preparative HPLC
  3. customyielding 10 mg

출처 및 근거

ORD 기록
ord-afe93530b68c4c44afbddeeb0e91daec
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511145B2

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