Methanesulfonyl chloride → HCID 20189890, 화합물

HRID 1788640노트

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HRID 1788640 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH:8]([CH2:12][CH2:13][CH3:14])[CH2:9][CH2:10][OH:11]>N1C=CC=CC=1.O>[CH3:1][S:2]([O:11][CH2:10][CH2:9][CH:8]([CH2:7][O:6][S:2]([CH3:1])(=[O:4])=[O:3])[CH2:12][CH2:13][CH3:14])(=[O:4])=[O:3]

참가 물질

5

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 125082552-Propylbutane-1,4-diol

생성물 1

HCID 20189890HCID 20189890, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 1049Pyridine용매

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온도
0 °C

실험 절차

Methanesulphonyl chloride (16.95 g) was added dropwise to a stirred solution of 3-hydroxymethylhexan-1-ol (8.94 g) in pyridine (39.5 g), maintaining the temperature at less than 5° C. Following the addition, the reaction mixture was stirred at 0° C. for 1.5 hours, then diluted with water and extracted with dichloromethane. The extracts were washed successively with water, dilute hydrochloric acid (X 2), water, aqueous sodium bicarbonate, and water, then dried over magnesium sulphate and concentrated to give 3-methanesulphonyloxymethylhex-1-yl methanesulphonate. (16.13 g, 83%) as a yellow oil.

후처리

  1. temperaturemaintaining the temperature at less than 5° C
  2. additionthe addition
  3. extractionextracted with dichloromethane
  4. washThe extracts were washed successively with water, dilute hydrochloric acid (X 2), water, aqueous sodium bicarbonate, and water
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b735e5a5475e4b5385211bc2dd514f1b
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04684396

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