Isatoic Anhydride → 2-amino-N-(3-imidazol-1-ylpropyl)benzamide

HRID 1788681노트

반응식

HRID 1788681 반응식
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[NH:13]1[CH:17]=[CH:16][N:15]=[C:14]1CCCN>C1(C)C=CC=CC=1>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:6][CH2:7][CH2:1][CH2:11][N:15]1[CH:16]=[CH:17][N:13]=[CH:14]1)=[O:4]

참가 물질

4

반응물 2

HCID 8359Isatoic AnhydrideHCID 132907973-(1H-Imidazol-2-yl)propan-1-amine

생성물 1

HCID 27983352-amino-N-(3-imidazol-1-ylpropyl)benzamide

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
90 °C

실험 절차

A mixture of 2.93 g of isatoic anhydride, 2.50 g of 1H-imidazole-propanamine and 30 ml of toluene was heated at 90° C. for 45 minutes and cooled. The toluene layer was decanted and the residue was dissolved in methylene chloride, washed with dilute sodium hydroxide solution, water and dried over magnesium sulfate. The organic layer was concentrated to obtain the desired product, mp 107°-110° C.

후처리

  1. temperaturecooled
  2. customThe toluene layer was decanted
  3. dissolutionthe residue was dissolved in methylene chloride
  4. washwashed with dilute sodium hydroxide solution, water
  5. dry with materialdried over magnesium sulfate
  6. concentrationThe organic layer was concentrated

출처 및 근거

ORD 기록
ord-fc25cc5cc9dc4f369eadfd7bf10dd010
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04684654

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