Methylparaben → HCID 54331531, 화합물

HRID 1788770노트

반응식

HRID 1788770 반응식
[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[CH2:12]([CH:14]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:15]Cl)[CH3:13].C[O-].[Na+]>CN(C)C=O>[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:15][CH:14]([CH2:12][CH3:13])[CH2:17][CH2:18][CH2:19][CH3:20])=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 7456MethylparabenHCID 312402-Ethylhexyl chlorideHCID 10942334Sodium Methoxide

생성물 1

HCID 54331531HCID 54331531, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 51.7 g (0.34 mol) of 4-hydroxybenzoic acid methylester, 500 ml of dimethyl formamide, 60 g (0.40 mol) of 2-ethylhexylchloride and 21.8 g (0.40 mol) of sodium methylate was heated for 7 hours to boiling temperature and, after cooling and removal of the sodium chloride by filtration, was evaporated to dryness under reduced pressure. The residue was dissolved in methylene chloride and chromatographed (eluent: methylene chloride) on silica gel (Merck) to yield 43 g (48% of the theoretical) of 4-(2-ethylhexyloxy)benzoic acid methylester. A refractive index of

후처리

  1. temperaturewas heated for 7 hours
  2. temperatureafter cooling
  3. customremoval of the sodium chloride
  4. filtrationby filtration
  5. customwas evaporated to dryness under reduced pressure
  6. dissolutionThe residue was dissolved in methylene chloride
  7. customchromatographed (eluent: methylene chloride) on silica gel (Merck)

출처 및 근거

ORD 기록
ord-145a27aebfd74767a69e19e03a8c59f6
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04684665

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