Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Nitro-4-benzoylphenylacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Diethyl 2-nitro-4-benzoylphenylmalonate | HCID 13408230 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-Nitro-4-benzoylphenylacetic acid | HCID 13770536 | 95% |
반응 단계
A mixture of 14 g. (36.3 mmoles) of diethyl 2-nitro-4-benzoylphenylmalonate, 300 ml. of 4N hydrochloric acid and 300 ml. of dioxane was heated to reflux for 10 hours. The reaction mixture was concentrated in vacuo and the crude product was triturated with hot methylene chloride, 9.88 g. (95% yield), m.p. 168°-170° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04686224 |
| 출처 데이터셋 | uspto-grants-1987_08 |
| ORD ID | ord-abaea9c2d3f2432c870e6577b3d1cda8 |
| 출처 메모 | uspto-grants-1987_08 |