Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Nitrobenzaldehyde → Diethyl 1,2,3,4-tetrahydro-2-hydroxy-6-methyl-4-(3-nitrophenyl)-2-(trifluoromethyl)-3,5-pyridine-dicarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Nitrobenzaldehyde | HCID 7449 | — |
| 반응물 | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| 반응물 | 2-Butenoic acid, 3-amino-, ethyl ester | HCID 95308 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Diethyl 1,2,3,4-tetrahydro-2-hydroxy-6-methyl-4-(3-nitrophenyl)-2-(trifluoromethyl)-3,5-pyridine-dicarboxylate | HCID 20189336 | 21.3% |
반응 단계
3-Nitrobenzaldehyde (3.0 g, 20 mmoles), ethyl 3-amino-2-butenoate (2.6 g, 20 mmoles) and ethyl 4,4,4-trifluoro-3-oxobutanoate (2.92 ml, 20 mmoles) were heated at reflux in ethanol (25 ml) for 6 hours. The solvent was removed in vacuo and the residue crystallised by the addition of ether/petroleum ether (60°-80°). The resulting solid was recrystallised from ether/petroleum ether (60°-80°) to give the title compound as colourless crystals (1.9 g) mp 120°-1°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04686217 |
| 출처 데이터셋 | uspto-grants-1987_08 |
| ORD ID | ord-4363dabc83874b53a061e880dad7c775 |
| 출처 메모 | uspto-grants-1987_08 |