Methanesulfonyl isocyanate → HCID 13768039, 화합물

HRID 1789354노트

반응식

HRID 1789354 반응식
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH:23]3[NH:27][CH2:26][CH2:25][S:24]3)[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:28][S:29]([N:32]=[C:33]=[O:34])(=[O:31])=[O:30]>CC(C)=O>[CH3:28][S:29]([NH:32][C:33]([N:27]1[CH2:26][CH2:25][S:24][CH:23]1[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[O:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)[CH2:9][CH2:10]1)=[O:34])(=[O:31])=[O:30]

참가 물질

4

반응물 2

HCID 12668338Methanesulfonyl isocyanateHCID 13768101HCID 13768101, 화합물

생성물 1

HCID 13768039HCID 13768039, 화합물수율 61.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

1.94 g of 2-{2-[2-(4-(3-fluorophenyl)piperazin-1-yl)ethyloxy]phenyl}thiazolidine are dissolved in anhydrous acetone, and 0.73 g of methanesulfonyl isocyanate is added thereto at room temperature. After the mixture is stirred for 30 minutes, the mixture is concentrated under reduced pressure to remove solvent. The residue is collected by filtration, and washed with water and ether, successively. The crude product thus obtained is recrystallized from a mixture of acetone and ether. 1.56 g of N-methanesulfonyl-2-{2-[2-(4-(3-fluorophenyl)piperazin-1-yl)ethyloxy]phenyl}thiazollidine-3-carboxamide are obtained.

후처리

  1. customat room temperature
  2. concentrationthe mixture is concentrated under reduced pressure
  3. customto remove solvent
  4. filtrationThe residue is collected by filtration
  5. washwashed with water and ether
  6. customThe crude product thus obtained
  7. customis recrystallized from a mixture of acetone and ether

출처 및 근거

ORD 기록
ord-4309e47a359d4d8aa7980c2c2a42a140
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04689327

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