Hydrogen Peroxide → 1-(2-benzoyloxyethyl)-1H-imidazo[4,5-c]-quinolin-5-oxide

HRID 1789417노트

반응식

HRID 1789417 반응식
[C:1]([O:9][CH2:10][CH2:11][N:12]1[C:24]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]=[CH:16][C:15]=2[N:14]=[CH:13]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:25]O>C(O)(=O)C>[C:1]([O:9][CH2:10][CH2:11][N:12]1[C:24]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N+:17]([O-:25])=[CH:16][C:15]=2[N:14]=[CH:13]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 139584231-(2-benzoyloxyethyl)-1H-imidazo[4,5-c]quinoline

생성물 1

HCID 139584241-(2-benzoyloxyethyl)-1H-imidazo[4,5-c]-quinolin-5-oxide

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
65 °C

실험 절차

A mixture of 67.5 g (0.213 mole) of 1-(2-benzoyloxyethyl)-1H-imidazo[4,5-c]quinoline (from Example 115), 36.3 g (0.32 mole) of 30% hydrogen peroxide and 450 ml of glacial acetic acid was heated at 65° C. for 2 days with stirring. The solution was evaporated in vacuo, and the residue was then added to water. The mixture was neutralized with aqueous sodium hydroxide solution and sodium bicarbonate. The solid was separated by filtration, washed with water and recrystallized form methanol to provide tan solid 1-(2-benzoyloxyethyl)-1H-imidazo[4,5-c]-quinolin-5-oxide.

후처리

  1. customThe solution was evaporated in vacuo
  2. additionthe residue was then added to water
  3. customThe solid was separated by filtration
  4. washwashed with water
  5. customrecrystallized
  6. customform methanol

출처 및 근거

ORD 기록
ord-e947c30edcac4d5f85af4d0febdc8b90
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04689338

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