1-Heptyl-1H-imidazole → HCID 178443957, 화합물

HRID 1789468노트

반응식

HRID 1789468 반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[CH2:26]([N:33]1[CH:37]=[CH:36][N:35]=[CH:34]1)[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]>>[CH3:25][C:22]1[CH:21]=[CH:20][C:19]([S:16]([O-:18])(=[O:17])=[O:15])=[CH:24][CH:23]=1.[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][N+:35]2[CH:36]=[CH:37][N:33]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH:34]=2)=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

참가 물질

3

반응물 2

HCID 1866691-Heptyl-1H-imidazoleHCID 538442024-Methylbenzenesulfonic acid 4-(4-acetylaminophenyl)butyl ester

생성물 1

HCID 178443957HCID 178443957, 화합물

실험 절차

Heat a mixture of 6.23 g (0.017 mole) 4-methylbenzenesulfonic acid 4-(4-acetylaminophenyl)butyl ester and 2.9 g (0.017 mole) 1-heptyl-1H-imidazole to 80° C., for 5 hours, following the reaction by thin-layer chromatography on silica gel (acetonitrile: ammonium hydroxide, 90:10). At the completion of the reaction, triturate the cooled resultant material with petroleum ether. Recrystallize the material from 25 ml hot methyl ethyl ketone with hot filtration, chill and seed to obtain the title compound.

후처리

  1. temperatureHeat
  2. customthe reaction by thin-layer chromatography on silica gel (acetonitrile: ammonium hydroxide, 90:10)
  3. customAt the completion of the reaction
  4. customtriturate the
  5. temperaturecooled resultant material with petroleum ether
  6. customRecrystallize the material from 25 ml hot methyl ethyl ketone
  7. filtrationwith hot filtration
  8. temperaturechill

출처 및 근거

ORD 기록
ord-65a238fbcc58467ca44415ceb2512a3b
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04689341

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