Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1789512생성일: 2026년 10월 25일
Sodium Iodide → N-[[1-[3-[4-fluoro-2-(phenylmethoxy)phenoxy]propyl]-4-piperidinyl]methyl]-2-benzothiazolamine
https://huagongshe.com/reaction/1789512
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | N-(4-piperidinylmethyl)-2-benzothiazolamine dihydrobromide | HCID 14048948 | — |
| 반응물 | 1-(3-Chloropropoxy)-4-fluoro-2-(phenylmethoxy)benzene | HCID 21241619 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | N-[[1-[3-[4-fluoro-2-(phenylmethoxy)phenoxy]propyl]-4-piperidinyl]methyl]-2-benzothiazolamine | HCID 14048965 | 65.2% |
반응 단계
A mixture of 3.2 parts of 1-(3-chloropropoxy)-4-fluoro-2-(phenylmethoxy)benzene, 4.1 parts of N-(4-piperidinylmethyl)-2-benzothiazolamine dihydrobromide, 6 parts of sodium carbonate, 0.1 parts of sodium iodide and 67.5 parts of N,N-dimethylacetamide was stirred overnight at 75° C. Water was added and the product was extracted with 4-methyl-2-pentanone. The extract was dried, filtered and evaporated. The oily residue was crystallized from acetonitrile. The product was filtered off and dried, yielding 3.3 parts (65.2%) of N-[[1-[3-[4-fluoro-2-(phenylmethoxy)phenoxy]propyl]-4-piperidinyl]methyl]-2-benzothiazolamine; mp. 129.5° C. (compound 24).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04689330 |
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| 출처 데이터셋 | uspto-grants-1987_08 |
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| ORD ID | ord-b15535aa13964aff82f7738b038b6fa8 |
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| 출처 메모 | uspto-grants-1987_08 |
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