Water → 1-Bromo-4-ethoxy-2-(trifluoromethyl)benzene

HRID 1789630노트

반응식

HRID 1789630 반응식
[Br:1]Br.[CH2:3]([O:5][C:6]1[CH:7]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:10][CH:11]=1)[CH3:4].O>CCOCC>[Br:1][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:3][CH3:4])=[CH:7][C:8]=1[C:12]([F:13])([F:14])[F:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 184153071-Ethoxy-3-(trifluoromethyl)benzene

생성물 1

HCID 220349931-Bromo-4-ethoxy-2-(trifluoromethyl)benzene수율 76.9%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Bromine (18.2 g) was slowly added dropwise to Compound (b) (19.3 g) at room temperature, and then the mixture was stirred at room temperature for 1 hour. Water and ether were added for liquid separation, and the aqueous layer was extracted three times with ether. The organic layers were combined, washed with saturated aqueous sodium bicarbonate and water, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 21.0 g of Compound (c).

후처리

  1. extractionthe aqueous layer was extracted three times with ether
  2. washwashed with saturated aqueous sodium bicarbonate and water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-e2b1c3cd2a7f482abbd02b5942d73d0c
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07070838B2

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