Boron tribromide → 2-Trifluoromethylhydroquinone

HRID 1789633노트

반응식

HRID 1789633 반응식
B(Br)(Br)Br.C([O:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([C:15]([F:18])([F:17])[F:16])[CH:9]=1)C>ClCCl>[F:16][C:15]([F:17])([F:18])[C:10]1[CH:9]=[C:8]([OH:7])[CH:13]=[CH:12][C:11]=1[OH:14]

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 220349974-Ethoxy-2-(trifluoromethyl)phenol

생성물 1

HCID 111166062-Trifluoromethylhydroquinone수율 63.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
-78 °C

실험 절차

Boron tribromide (11.8 g) was slowly added dropwise to dichloromethane (41 mL) cooled to −78° C., and then Compound (e) (6.47 g) dissolved in dichloromethane (60 mL) was slowly added dropwise at the same temperature and the mixture was stirred at room temperature for 2 hours. The reaction mixture was then poured into ice water and the aqueous layer was extracted with ether. The organic layers were combined, washed with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 3.53 g of Compound (g).

후처리

  1. additionwas slowly added dropwise at the same temperature
  2. extractionthe aqueous layer was extracted with ether
  3. washwashed with saturated aqueous sodium chloride
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-3eaf5a5c4504444dad2bbf538ca8f3b7
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07070838B2

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