Aniline → 4'-Methylbenzanilide

HRID 1789655

반응식

HRID 1789655 반응식
Cl[CH2:2]Cl.[NH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[C:11]1(C)[CH:16]=[CH:15][C:14]([C:17](Cl)=[O:18])=[CH:13][CH:12]=1>CCOCC>[CH3:2][C:8]1[CH:9]=[CH:10][C:5]([NH:4][C:17](=[O:18])[C:14]2[CH:15]=[CH:16][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 6115AnilineHCID 6344DichloromethaneHCID 134054-Methylbenzoyl Chloride

생성물 1

HCID 684974'-Methylbenzanilide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a 0° C. dichloromethane (300 mL) solution of 25 mL (274 mmol) of aniline was added 16 mL (123 mmol) para-toluoyl chloride over 10 min. The mixture was stirred at room temperature for 0.5 h, treated with 200 mL of ether and filtered immediately. The filtrate was washed with 1 M HCl (2×50 mL), 0.1 M NaOH (2×50 mL), and saturated aqueous ammonium chloride, dried over Na2SO4 and concentrated. Para-methylbenzanilide (17.3 g) was obtained as a tan solid and used directly.

후처리

  1. filtrationfiltered immediately
  2. washThe filtrate was washed with 1 M HCl (2×50 mL), 0.1 M NaOH (2×50 mL), and saturated aqueous ammonium chloride
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4706a63b928d4b74b43d4d6ac8d84992
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071177B2

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