Cycloheptanone → N-Cycloheptylglycine

HRID 1789784노트

반응식

[C:1]1(=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C[O:10][C:11](=[O:14])[CH2:12][NH2:13]>>[CH:1]1([NH:13][CH2:12][C:11]([OH:14])=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 10400Cycloheptanone

HCID 69221Glycine methyl ester

생성물 1

HCID 21197386N-Cycloheptylglycine

실험 절차

N-Cycloheptylglycine was synthesized by reductive amination of cycloheptanone with glycine methyl ester following the procedure described in Gera et al., Immunopharmacology. 33:174–177 (1996). The crude product was converted to the N-Boc derivative (mp, 89–90° C.).

출처 및 근거

ORD 기록: ord-4d12ac80a56d479baf43142f1db2788d
출처 데이터셋: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07071168B2

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