Potassium Hydroxide → 2,4-Bis[[(3-chloro-2-fluorophenyl)methyl]thio]-7-pteridinamine

HRID 1789944노트

반응식

HRID 1789944 반응식
[NH2:1][C:2]1[C:7]([NH:8][CH2:9][C:10]#[N:11])=[C:6]([S:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=2[F:21])[N:5]=[C:4]([S:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:25]=2[F:31])[N:3]=1.[OH-].[K+]>CO.ClCCl>[Cl:30][C:26]1[C:25]([F:31])=[C:24]([CH2:23][S:22][C:4]2[N:5]=[C:6]([S:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=3[F:21])[C:7]3[C:2](=[N:1][C:10]([NH2:11])=[CH:9][N:8]=3)[N:3]=2)[CH:29]=[CH:28][CH:27]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 22037040[[4-Amino-2,6-bis[[(3-chloro-2-fluorophenyl)methyl]thio]-5-pyrimidinyl]amino]acetonitrile

생성물 1

HCID 220370352,4-Bis[[(3-chloro-2-fluorophenyl)methyl]thio]-7-pteridinamine

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

A solution of the product from example 13, step (b) (1.4 g) and potassium hydroxide (110 mg) in methanol (80 ml) and dichloromethane (120 ml) was stirred at room temperature for 24 hours. After evaporation in vacuo, the residue rendered the subtitled compound as a pale yellow solid (1.4 g).

후처리

  1. customAfter evaporation in vacuo

출처 및 근거

ORD 기록
ord-8b0ef7003d124452b8d43d2ab90b786d
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071193B2

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