Toluene → HCID 86588863, 화합물

HRID 1790194노트

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HRID 1790194 반응식
C1(C)C=CC=CC=1.N1CCCCC1.[CH3:14][N:15]1[C:24]2[C:19](=[CH:20][C:21]([CH3:38])=[C:22]([C:25]3[CH:26]=[C:27]([CH:30]=[CH:31][C:32]=3[O:33][C:34]([F:37])([F:36])[F:35])[CH:28]=O)[CH:23]=2)[C:18]([CH3:40])([CH3:39])[CH2:17][C:16]1=[O:41].[CH3:42][N:43]1[C:47](=[O:48])[CH2:46][S:45][C:44]1=[O:49]>C(OCC)(=O)C.C(O)(=O)C>[CH3:42][N:43]1[C:47](=[O:48])[C:46](=[CH:28][C:27]2[CH:30]=[CH:31][C:32]([O:33][C:34]([F:37])([F:36])[F:35])=[C:25]([C:22]3[CH:23]=[C:24]4[C:19]([C:18]([CH3:39])([CH3:40])[CH2:17][C:16](=[O:41])[N:15]4[CH3:14])=[CH:20][C:21]=3[CH3:38])[CH:26]=2)[S:45][C:44]1=[O:49]

참가 물질

7

반응물 4

HCID 1140TolueneHCID 8082PiperidineHCID 12820623-Methyl-1,3-thiazolidine-2,4-dioneHCID 21966438HCID 21966438, 화합물

생성물 1

HCID 86588863HCID 86588863, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of toluene (80 mL), piperidine (380 μL), acetic acid (380 μL), 3-(1,4,4,6-Tetramethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-trifluoromethoxy-benzaldehyde (7.5 g, 19.16 mmol) and a 3-alkyl—thiazolidine-2,4-dione such as 3-Methyl-thiazolidine-2,4-dione (19.16 mmol) is heated at reflux overnight. The reaction mixture is cooled to room temperature, diluted with ethyl acetate and is washed with water and brine, dried over MgSO4. The residue is recrystallized to afford 3-methyl-5-[3-(1,4,4,6-tetramethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-trifluoromethoxy-benzylidene]-thiazolidine-2,4-dione.

후처리

  1. temperatureat reflux overnight
  2. washis washed with water and brine
  3. dry with materialdried over MgSO4
  4. customThe residue is recrystallized

출처 및 근거

ORD 기록
ord-5b00ee9768ad48a898dd923a0cb62874
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071218B2

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