2,4-Difluorophenethyl bromide → 1-[1-(2,4-Difluorophenethyl)-piperdin-4-yl]-6-bromoindoline

HRID 1790476

반응식

HRID 1790476 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Br:16])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[F:17][C:18]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:19]=1[CH2:20][CH2:21]Br>>[F:17][C:18]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:19]=1[CH2:20][CH2:21][N:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Br:16])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 112989892,4-Difluorophenethyl bromideHCID 220381701-(Piperidin-4-yl)-6-bromoindoline

생성물 1

HCID 220383091-[1-(2,4-Difluorophenethyl)-piperdin-4-yl]-6-bromoindoline수율 60.1%

실험 절차

1-(Piperidin-4-yl)-6-bromoindoline (3.0 g) and 2,4-difluorophenethyl bromide (3.1 g) were treated as in Example 2 to give the title compound (2.7 g) as a white powder (yield: 60%).

출처 및 근거

ORD 기록
ord-232ee03a698e48479f56307e26524ce8
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071201B2

연결된 노트

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