1-(3-Bromopropoxy)-4-fluorobenzene → 1-[1-(4-Fluorophenoxypropyl)-piperdin-4-yl]-6-bromoindoline

반응식

[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Br:16])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[F:17][C:18]1[CH:28]=[CH:27][C:21]([O:22][CH2:23][CH2:24][CH2:25]Br)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:28]=[CH:27][C:21]([O:22][CH2:23][CH2:24][CH2:25][N:1]2[CH2:6][CH2:5][CH:4]([N:7]3[C:15]4[C:10](=[CH:11][CH:12]=[C:13]([Br:16])[CH:14]=4)[CH2:9][CH2:8]3)[CH2:3][CH2:2]2)=[CH:20][CH:19]=1

참가 물질

반응물 2

HCID 2600041-(3-Bromopropoxy)-4-fluorobenzene

HCID 220381701-(Piperidin-4-yl)-6-bromoindoline

생성물 1

HCID 233774761-[1-(4-Fluorophenoxypropyl)-piperdin-4-yl]-6-bromoindoline수율 90%

실험 절차

1-(Piperidin-4-yl)-6-bromoindoline (1.6 g) and 4-fluorophenoxypropyl bromide (1.6 g) were treated as in Example 2 to give the title compound (2.2 g) as a white powder (yield: 90%).

출처 및 근거

ORD 기록: ord-d29c7b7a24244799ba89050c6599dab3
출처 데이터셋: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07071201B2

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