1-[2-(4-Fluorophenyl)ethyl]piperidin-4-one → 6-bromo-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

반응식

[CH3:1][C:2]1([CH3:12])[C:10]2[C:5](=[CH:6][C:7]([Br:11])=[CH:8][CH:9]=2)[NH:4][CH2:3]1.FC1C=CC(CCN2CCC(=[O:28])CC2)=CC=1>>[CH3:1][C:2]1([CH3:12])[C:10]2[C:5](=[CH:6][C:7]([Br:11])=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:28]

참가 물질

반응물 2

HCID 70235941-[2-(4-Fluorophenyl)ethyl]piperidin-4-one

HCID 107044106-Bromo-3,3-dimethylindoline

생성물 1

HCID 106576496-bromo-3,3-dimethyl-2,3-dihydro-1H-indol-2-one수율 89.2%

실험 절차

3,3-Dimethyl-6-bromoindoline (3.10 g), 1-[2-(4-fluorophenyl)ethyl]-4-piperidone (2.81 g) and triacetoxylated sodium borohydride (5.70 g) were treated as in Example 16 to give the title compound (2.72 g) as a white amorphous solid (yield: 49.8%).

출처 및 근거

ORD 기록: ord-f23be0e308a34927aa7afcab7bc48bcb
출처 데이터셋: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07071201B2

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