Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1790695생성일: 2026년 10월 27일
Methyl iodide → 4-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzodiazol-6-yl}oxy)-N-methylpyridine-2-carboxamide
https://huagongshe.com/reaction/1790695
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 4-Bromophenyl isothiocyanate | HCID 16133 | — |
| 반응물 | {4-[4-Amino-3-(methylamino)phenoxy](2-pyridyl)}-n-methylcarboxamide | HCID 58385469 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzodiazol-6-yl}oxy)-N-methylpyridine-2-carboxamide | HCID 22040978 | — |
반응 단계
A solution of the {4-[4-amino-3-(methylamino)phenoxy](2-pyridyl)}-N-methyl-carboxamide(1 eq) in methanol was treated with 4-bromophenylisothiocyanate (1 eq) and stirred at 60° C. for 2 hours. The reaction mixture was cooled down to room temperature and iodomethane (1 eq) was added and stirred overnight at 60° C. The reaction was concentrated and preparative chromatography gave (4-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-6-yloxy}-(2-pyridyl)-N-methylcarboxamide. MS: MH+=452.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07071216B2 |
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| 출처 데이터셋 | uspto-grants-2006_07 |
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| ORD ID | ord-204e0e7bf12a4fd99666168d14b4e1c1 |
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| 출처 메모 | uspto-grants-2006_07 |
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