Water → [1-(2-Methyl-1,3-dioxolan-2-yl)cyclopropyl]methanol

HRID 1790878노트

반응식

HRID 1790878 반응식
C[O:2][C:3]([C:5]1([C:8]2([CH3:13])[O:12][CH2:11][CH2:10][O:9]2)[CH2:7][CH2:6]1)=O.CC(C[AlH]CC(C)C)C.C(O)(C)C.O>C1(C)C=CC=CC=1>[CH3:13][C:8]1([C:5]2([CH2:3][OH:2])[CH2:7][CH2:6]2)[O:9][CH2:10][CH2:11][O:12]1

참가 물질

6

반응물 4

HCID 962WaterHCID 3776IsopropanolHCID 14487Diisobutylaluminum hydrideHCID 18725787HCID 18725787, 화합물

생성물 1

HCID 22042312[1-(2-Methyl-1,3-dioxolan-2-yl)cyclopropyl]methanol

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
0 °C

실험 절차

11.2 g of 5 is dissolved in 150 ml of toluene and cooled under nitrogen to 0° C. 125 ml of DIBAH solution (1.2 M in toluene) is now slowly added in drops and stirred for 2 more hours. Then, 1.25 ml of isopropanol and 25 ml of water are added in drops and stirred overnight. The precipitate is filtered off, the filtrate is concentrated by evaporation and chromatographed on silica gel with ethyl acetate/hexane, whereby 9.1 of title compound 6 accumulates as a colorless oil.

후처리

  1. stirringstirred overnight
  2. filtrationThe precipitate is filtered off
  3. concentrationthe filtrate is concentrated by evaporation
  4. customchromatographed on silica gel with ethyl acetate/hexane, whereby 9.1 of title compound 6 accumulates as a colorless oil

출처 및 근거

ORD 기록
ord-defb7654daa34a208c68c11dbb800b7a
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071344B1

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